SEGPHOS®是繼BINAP之后發(fā)現(xiàn)的一種應(yīng)用于不對(duì)稱反應(yīng)中的手性配體，它的芳香環(huán)之間具有較狹窄的二面角，因此SEGPHOS®能增加金屬配合物的對(duì)映選擇性與活性。百靈威提供STREM品牌SEGPHOS®配體及釕催化劑，適用底物廣、催化活性高（TOF可達(dá)30,000以上，用量少、成本低）、對(duì)映選擇性好（ee＞95%，純化更簡(jiǎn)單）、收率高（可達(dá)99%），供貨穩(wěn)定，可有效幫助您加快科研進(jìn)程。
SEGPHOS® 配體
Technical Notes:
1. Iridium-catalyzed asymmetric hydrogenation of quinolines activated by chloroformates.
2. Diastereo- and enantioselective ruthenium-catalyzed hydrohydroxyalkylation of 2-silyl-butadienes.
3. Asymmetric Ag-catalyzed cycloadditions.
References:
1. Angew. Chem. Int. Ed., 2006, 45, 2260.
2. J. Am. Chem. Soc., 2011, 133, 10582.
3. J. Org. Chem., 2011, 76, 1945.
96-6900 Takasago SEGPHOS® Ligand Kit
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15-0136
(R)-(+)-5,5'-Bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole, min. 98%
(R)-(+)-SEGPHOS®[244261-66-3]
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15-0137
(S)-(-)-5,5'-Bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole, min. 98%
(S)-(-)-SEGPHOS®[210169-54-3]
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15-0478
(R)-(+)-5,5'-Bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98%
(R)-(+)-DM-SEGPHOS®[850253-53-1]
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15-0479
(S)-(-)-5,5'-Bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98%
(S)-(-)-DM-SEGPHOS®[210169-57-6]
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15-0066
(R)-(-)-5,5'-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98%
(R) -(-)-DTBM- SEGPHOS® [566940-03-2]
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15-0067
(S)-(+)-5,5'-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98%
(S)-(+)-DTBM- SEGPHOS® [210169-40-7]
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SEGPHOS® 釕類催化劑
Technical Notes:
1. Highly active highly enantioselective catalyst for hydrogenation of functionalized ketones. Slightly higher temperature is necessary to activate the cymene complexes. Asymmetric hydrogenation of α-substituted-β-alkyl-β-ketoesters accompanied by dynamic kinetic resolution.
2. Highly enantioselective, highly active catalyst for hydrogenation of functionalized ketones. The chlororuthenate salts show catalytic activity at relatively low temperature.
3. Biaryl bisphosphine ligand with narrow dihedral angle. The DM-SEGPHOS ligand, as the ruthenium complex, gives superior enantioselectivity and diastereoselectivity in the asymmetric hydrogenation of α-substituted-β-ketoesters. Ruthenium catalyzed enantioselective synthesis of β amino acids by hydrogenation.
Reference:
1. U.S. Pat. 7038087.
2. Adv. Synth. Catal., 2001, 343, 264.
3. WIPO Pat. WO2005028419.+
Takasago SEGPHOS® Ru Cymene Catalysts
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44-0096
Chloro[(R)-(+)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole](p-cymene)ruthenium(II)chloride[RuCl(p-cymene)
((R)-segphos®)]Cl [944451-28-9]
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44-0097
Chloro[(S)-(-)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole](p-cymene)ruthenium(II)chloride[RuCl(p-cymene)
((S)-segphos®)]Cl [944451-29-0]
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44-0098
Chloro{(R)-(+)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}(p-cymene)ruthenium(II)chloride[RuCl(p-cymene)
((R)-dm- segphos®)]Cl [944451-30-3]
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44-0099
Chloro{(S)-(-)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}(p-cymene)ruthenium(II)chloride[RuCl(p-cymene)
((S)-dm- segphos®)]Cl [944451-31-4]
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44-0102
Chloro{(R)-(-)-5,5'-bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole}(p-cymene)ruthenium(II) chloride
[RuCl(p-cymene)((R)-dtbm- segphos®)]Cl [944451-32-5]
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44-0103
Chloro{(S)-(+)-5,5'-bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole}(p-cymene)ruthenium(II) chloride
[RuCl(p-cymene)((S)-dtbmsegphos®)]Cl [944451-33-6]
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Takasago SEGPHOS® Ru Dimer Catalysts
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44-0518
Dimethylammoniumdichlorotri(μ-chloro)bis[(R)-(+)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole]diruthenate(II)
[NH2Me2][{RuCl((R)-segphos®)}2(μ-Cl)3][346457-41-8]
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44-0519
Dimethylammoniumdichlorotri(μ-chloro)bis[(S)-(-)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole]diruthenate(II)
[NH2Me2][{RuCl((S)-segphos®)}2(μ-Cl)3][488809-34-3]
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44-0520
Dimethylammoniumdichlorotri(μ-chloro)bis{(R)-(+)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}diruthenate(II)
[NH2Me2][{RuCl((R)-dm-segphos®)}2(μ-Cl)3] [935449-46-0]
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44-0521
Dimethylammoniumdichlorotri(μ-chloro)bis{(S)-(-)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzdioxole}diruthenate(II)
[NH2Me2][{RuCl((S)-dm-segphos®)}2(μ-Cl)3] [944451-14-3]
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Takasago SEGPHOS® Ru Acetate Catalysts
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44-0168
Diacetato[(R)-(+)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole]ruthenium(II)
Ru(OAc)2[(R)-segphos®][944450-48-0]
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44-0169
Diacetato[(S)-(-)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole]ruthenium(II)
Ru(OAc)2[(S)-segphos®][373650-12-5]
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44-0174
Diacetato{(R)-(+)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}ruthenium(II)
Ru(OAc)2[(R)-dm-segphos®][944450-49-1]
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44-0176
Diacetato{(S)-(-)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}ruthenium(II)
Ru(OAc)2[(S)-dm-segphos®][944450-50-4]
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Takasago SEGPHOS® Ru Diammine Catalysts
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44-0214
Dichloro{(R)-(+)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II)
RuCl2[(R)-dm-segphos®][(R)-daipen][944450-43-5]
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44-0215
Dichloro{(S)-(-)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}[(2S)-(+)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II)
RuCl2[(S)-dm-segphos®][(S)-daipen][944450-44-6]
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44-0228
Dichloro{(R)-(+)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}[(1R,2R)-(+)-1,2-diphenylethylenediamine]ruthenium(II)
RuCl2[(R)-dm-segphos®][(R,R)-dpen] [944450-45-7]
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44-0229
Dichloro{(S)-(-)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}[(1S,2S)-(-)-1,2-diphenylethylenediamine]ruthenium(II)
RuCl2[(S)-dm-segphos®][(S,S)-dpen] [944450-46-8]
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注：1、以上產(chǎn)品均為Takasago®專利產(chǎn)品；
2、可提供大包裝定制服務(wù)。