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蛋白質(zhì)交聯(lián)劑含有兩個(gè)或多個(gè)反應(yīng)性基團(tuán)，可以與蛋白或者其他分子上的官能團(tuán)如氨基和巰基反應(yīng)，使他們以共價(jià)鍵的方式結(jié)合在一起。蛋白質(zhì)交聯(lián)劑已被廣泛應(yīng)用于生命科學(xué)研究的各個(gè)分支,如蛋白質(zhì)間相互作用研究、蛋白質(zhì)結(jié)構(gòu)分析、蛋白質(zhì)組學(xué)、靶向藥物研究、蛋白質(zhì)或其他分子的固相化等[1]。

百靈威可以提供多種不同種類交聯(lián)劑，滿足您蛋白質(zhì)研究中的多樣化需求。

  • 種類齊全：包括氨基反應(yīng)性末端、氨基和巰基反應(yīng)性末端、巰基反應(yīng)性末端等
  • 性價(jià)比高
  • 現(xiàn)貨供應(yīng)
  • 獨(dú)家供應(yīng)新型化學(xué)交聯(lián)劑Leiker，具有可富集、可切斷、可定量的作用[2]。

參考文獻(xiàn):

[1] Sinz A. Divide and conquer: cleavable cross-linkers to study protein conformation and protein–protein interactions[J]. Analytical and bioanalytical chemistry, 2017, 409(1): 33-44.

[2] Tan D, Li Q, Zhang M J, et al. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states[J]. Elife Sciences, 2016, 5.

■   Leiker產(chǎn)品：

• 高效富集功能

• 交聯(lián)效率比傳統(tǒng)交聯(lián)劑高十倍以上

• 有效針對復(fù)雜蛋白樣品分析

產(chǎn)品編號(hào)

產(chǎn)品名稱

CAS號(hào)

純度

包裝規(guī)格

2138035

Leiker, 95%

賴氨酸特異性可富集型交聯(lián)劑

N/A

95%

5mg

10mg

2322681

d6-Leiker, 95%

d6-賴氨酸特異性可富集型交聯(lián)劑

N/A

95%

5mg

10mg

■   氨基-氨基交聯(lián)劑

產(chǎn)品編號(hào)

產(chǎn)品名稱

CAS號(hào)

純度

包裝規(guī)格

146482

BS3 (Suberic acid bis(3-sulfo-N-hydroxysuccinimide

ester) sodium salt), 90%

雙琥珀酰亞胺辛二酸酯鈉鹽

82436-77-9

90%

25ml

100ml

1410146

Disuccinimidyl tartrate, 90%

雙琥珀酰亞胺酒石酸酯

77658-91-4

90%

5mg

25mg

253405

DSS (Di(N-succinimidyl)suberate), 98%

二(N-羥基琥珀酰亞胺)辛二酸酯

68528-80-3

98%

1g

5g

296329

DSP (Di(N-succinimidyl) 3,3'-dithiodipropionate), 97%

二(N-羥基丁二酰亞胺) 3,3'-二硫代二丙酸酯

57757-57-0

97%

1g

5g

792543

DTSSP (3,3'-Dithiobispropionic acid bis-sulfosuccinimidyl ester), 90%

3,3'-二硫代雙(磺酸琥珀酰亞氨基丙酸酯)

81069-02-5

90%

25mg

100mg

456454

Di(N-succinimidyl) glutarate, 97%

二(N-羥基琥珀酰亞胺)戊二酸酯

79642-50-5

97%

50mg

250mg

2740589

Sulfo-EGS (Ethylene glycol bis(sulfosuccinimidyl succinate))

乙二醇雙(磺基琥珀酰亞胺基琥珀酸酯)

167410-92-6

N/A

10mg
50mg

359030

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester), 95%

乙二醇-雙(琥珀酸 N-羥基琥珀酰亞胺酯)

70539-42-3

95%

50mg

250mg

494597

Sebacic acid bis(N-succinimidyl) ester, 97%

癸二酸二(N-琥珀酰亞胺)酯

23024-29-5

97%

100mg

500mg

2742043

BS(PEG)5 (PEGylated bis(sulfosuccinimidyl)suberate)

聚乙二醇化雙（磺基琥珀酰亞胺）辛二酸酯

N/A

N/A

100mg

2742044

BS(PEG)9 (PEGylated bis(sulfosuccinimidyl)suberate)

聚乙二醇9化雙（磺基琥珀酰亞胺）辛二酸酯

1008402-79-6

N/A

100mg

2331953

mPEG-SC, average M.W.5000

甲氧基-PEG-琥珀酰亞胺碳酸酯, 平均分子量5000

N/A

N/A

1g

5g

350500

p-Phenylene diisothiocyanate, 98.5%

對苯二異硫氰酸酯

4044-65-9

98.5%

5g

475953

7-Hydroxy-4-methylcoumarin-3-acetic acid, succinimidyl ester, 90%

7-羥基-4-甲基香豆素-3-乙酸N-琥珀酰亞胺酯

96735-88-5

90%

25mg

928187

3β-Amino-3-deoxydigoxigenin hemisuccinamide,

succinimidyl ester, 80%, single isomer

3β-氨基-3-脫氧地高辛半琥珀酰胺, 琥珀酰亞胺酯,

單一化合物

216299-46-6

80%

5mg

■   氨基-巰基交聯(lián)劑

產(chǎn)品編號(hào)

產(chǎn)品名稱

CAS號(hào)

純度

包裝規(guī)格

253343

Sulfo-SMCC sodium, 95%

磺基-SMCC鈉鹽

92921-24-9

95%

25mg

100mg

918408

LC-SPDP (Succinimidyl 6-[3(2-

pyridyldithio)propionamido]hexanoate)

琥珀酰亞胺基6-[3（2-吡啶基二硫代）丙酰胺基]己酸酯

158913-22-5

95%

50mg

1682773

Maleimide-PEG2-succinimidyl ester, 99%

馬來酰亞胺-PEG2-琥珀酰亞胺酯

955094-26-5

99%

50mg

250mg

1880578

Maleimide-PEG8-succinimidyl ester, 80%

馬來酰亞胺-PEG8-琥珀酰亞胺酯

756525-93-6

80%

50mg

100mg

250mg

2744836

Maleimide-PEG12-succinimidyl ester

馬來酰亞胺-PEG12-琥珀酰亞胺酯

1426151-00-9

N/A

50mg

100mg

250mg

2743830

PEG4-SPDP(PEGylated, long-chain SPDP crosslinker)

聚乙二醇化的長鏈SPDP交聯(lián)劑

N/A

N/A

100mg

2743831

PEG12-SPDP(PEGylated, long-chain SPDP crosslinker)

聚乙二醇化的長鏈SPDP交聯(lián)劑

N/A

N/A

100mg

1880577

PEGylated, long-chain SMCC crosslinker

馬來酰亞胺-PEG6-琥珀酰亞胺酯

1137109-21-7

N/A

50mg

250mg

2739697

SBAP (Succinimidyl 3-(bromoacetamido)propionate),

90%

琥珀酰亞胺基3-(溴乙酰氨基)丙酸酯

57159-62-3

90%

10mg
50mg

2740592

SIAB (Succinimidyl (4-iodoacetyl)aminobenzoate)

SIAB(N-琥珀酰亞胺基[4-碘乙�；�]氨基苯甲酸酯)

72252-96-1

95%

50mg

2739698

SM(PEG)24 (PEGylated, long-chain SMCC crosslinker)

聚乙二醇化的長鏈SMCC交聯(lián)劑

N/A

N/A

25mg

100mg

2740596

Sulfo-EMCS (N-ε-Maleimidocaproyl-oxysulfosuccinimide ester)

N-ε-馬來酰亞胺己酰氧基磺基琥珀酰亞胺酯

 N/A

N/A

50mg

990207

Sulfo-KMUS(N-(κ-Maleimidoundecanoyloxy)

sulfosuccinimide ester)

N-(κ-馬來酰亞胺十一烷酰氧基)磺基琥珀酰亞胺酯

 N/A

96%

50mg

199829

Sulfo-LC-SPDP (Sulfosuccinimidyl 6-(3'-(2-

pyridyldithio)propionamido)hexanoate), 90%

磺基琥珀酰亞胺基6-[3′-(2-吡啶基二硫代)丙酰胺基]己酸

169751-10-4

90%

50mg

2740595

Sulfo-MBS (m-Maleimidobenzoyl-

N-hydroxysulfosuccinimide ester)

間馬來酰亞胺苯甲酰基-N-羥基磺基琥珀酰亞胺酯

103848-62-0

95%

10mg

50mg

2740597

Sulfo-SMPB (Sulfosuccinimidyl 4-(N-

maleimidophenyl)butyrate)

4-(N-馬來酰亞胺苯基)丁酸磺基琥珀酰亞胺基酯

 N/A

95%

10mg
50mg

771214

Sulfo-SIAB (Sulfosuccinimidyl (4-iodoacetyl)aminobenzoate)

磺基-N-琥珀酰亞胺基(N-碘乙�；�)氨基苯甲酸酯

144650-93-1

N/A

10mg

50mg

1318115

Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt

磺基-N-琥珀酰亞胺基4-馬來酰亞胺丁酸鈉鹽

185332-92-7

90%

5mg

25mg
50mg

415447

MBS (3-Maleimidobenzoic acid N-hydroxysuccinimide

ester)
3-馬來酰亞胺基苯甲酸琥珀酰亞胺酯, 98%

58626-38-3

98%

100mg

250mg

389641

SMPB (4-(4-Maleimidophenyl)butyric acid

N-hydroxysuccinimide ester)

4-(4-馬來酰亞胺基苯基)丁酸琥珀酰亞胺酯, 98%

79886-55-8

98%

100mg

551313

SPD (3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester)

3-(2-吡啶二硫代)丙酸 N-琥珀酰亞胺酯, 96%

68181-17-9

96%

100mg

444282

SIA (N-Succinimidyl iodoacetate)
碘乙酸N-琥珀酰亞胺酯, 95%

39028-27-8

95%

100mg

500mg

168877

Bromoacetic acid N-hydroxysuccinimide ester, 95%
溴乙酸 (N-羥基琥珀酰亞胺)酯, 95%

42014-51-7

95%

250mg

1g

316626

GMBS (4-Maleimidobutyric acid

N-hydroxysuccinimide ester) , 98%
4-馬來酰亞胺基丁酸N-羥基琥珀酰亞胺酯

80307-12-6

98%

100mg

250mg

141636

3-(Maleimido)propionic acid N-hydroxysuccinimide

ester, 99%

3-馬來酰亞胺基丙酸(N-羥基琥珀酰亞胺)酯

55750-62-4

99%

100mg

1g

229882

Maleimidoacetic acid N-hydroxysuccinimide ester,

98%

馬來酰亞胺基乙酸琥珀酰亞胺酯

55750-61-3

98%

10mg

50mg

245256

6-Maleimidohexanoic acid N-hydroxysuccinimide

ester, 98%

6-(馬來酰亞胺基)己酸(N-羥基琥珀酰亞胺)酯

55750-63-5

98%

100mg

1g

467057

N-Succinimidyl-4-(maleimidomethyl)cyclohexane-

1-carboxylate, 99%

N-琥珀酰亞胺基-4-(馬來酰亞胺基甲基)環(huán)己烷-1-羧酸酯

64987-85-5

99%

100mg

250mg

■   巰基-巰基交聯(lián)劑

產(chǎn)品編號(hào)

產(chǎn)品名稱

CAS號(hào)

純度

包裝規(guī)格

2739702

1,8-Bismaleimido diethylene glycol

1,8-雙馬來酰亞胺基二甘醇

N/A

90%

50mg

590530

1,2-Bismaleimidoethane, 95%

1,2-雙(馬來酰亞胺)乙烷

5132-30-9

95%

25mg

100mg

454643

1,6-Bismaleimidohexane, 97%

1,6-二(馬來酰亞胺基)己烷

4856-87-5

97%

25mg

100mg

2739701

BM(PEG)3 (1,11-Bismaleimido-triethyleneglycol)

1,11雙馬來酰亞胺基三甘醇

86099-06-1

98%

25mg

50mg

100mg

2742604

DTME (Dithiobismaleimidoethane)

二硫代雙馬來酰亞胺甲烷

N/A

N/A

50mg

■   巰基-羰基交聯(lián)劑

產(chǎn)品編號(hào)

產(chǎn)品名稱

CAS號(hào)

純度

包裝規(guī)格

2740604

KMUH (N-(κ-Maleimidoundecanoic acid) hydrazide,

trifluoroacetic acid salt)

KMUH(N-(κ-馬來酰亞胺基十一烷酸)酰肼

1593661-78-9

97%

50mg

507400

PDPH (3-(2-Pyridyldithio)propionyl hydrazide)

3-（2-吡啶基二硫代）丙酰肼

115616-51-8

95%

25mg

50mg

424909

EMCH (N-(ε-Maleimidocaproic acid) hydrazide,

trifluoroacetic acid salt), 95%

6-馬來酰亞胺己酰肼三氟乙酸鹽

151038-94-7

95%

50mg

250mg

380294

4-(4-N-Maleimidophenyl) butyric acid hydrazide, 80%

4-(4-N-馬來酰亞胺苯基)丁酸酰肼

157797-94-9

80%

50mg

■   光反應(yīng)性交聯(lián)劑

產(chǎn)品編號(hào)

產(chǎn)品名稱

CAS號(hào)

純度

包裝規(guī)格

350636

4-Benzoylbenzoic acid N-succinimidyl ester, 97%

4-苯甲酰苯甲酸-N-琥珀酰亞胺酯

91990-88-4

97%

50mg

250mg

■   其他反應(yīng)基團(tuán)交聯(lián)劑

產(chǎn)品編號(hào)

產(chǎn)品名稱

CAS號(hào)

純度

包裝規(guī)格

902042

Glutaraldehyde, 50 wt.% solution in H2O

戊二醛, 50 wt.% 水溶液

111-30-8

N/A

25ml

100ml

500ml

211112

EDC (N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide

hydrochloride)

N-(3-二甲氨基丙基)-N'-乙基碳二亞胺鹽酸鹽

25952-53-8

99%

1g

10g

50g

100g

117997

NHS(N-Hydroxysuccinimide)

N-羥基琥珀酰亞胺

6066-82-6

98%

5g

25g

100g

1921678

N-DiZPK, 98%

N-DiZPK

1337883-32-5

98%

10mg

202233

Adipic acid dihydrazide, 98%

己二酸二酰肼

1071-93-8

98%

5g

25g

250g

2669832

O-DiZPK, 98%

O-DiZPK

N/A

98%

10mg


 

 

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